All Specialties
Until recently, there were no effective medications for cardiac amyloidosis. We could only treat the symptoms and refer patients for heart transplants. Today, thanks in part to cutting edge clinical trials done at Ochsner, exciting new therapies are available. With rapid diagnosis and multidisciplinary management from the experienced team at Ochsner, it’s a new day for patients with what is sometimes called “stiff heart syndrome.” Longer, healthier lives are now possible for people with this diagnosis.
What is Cardiac Amyloidosis?
Cardiac amyloidosis occurs when abnormal proteins called amyloids build up and form deposits in your heart, essentially taking the place of normal heart muscle. This buildup causes the heart to become stiff, reducing the heart's ability to fill with blood between heartbeats. Cardiac amyloidosis can also affect the kidneys, nerves, blood, bowel, rectum, liver and mouth.
While there is no cure, treatments available at Ochsner can limit the production of amyloid protein and help you manage your symptoms. We have diagnostic equipment for amyloidosis you won’t find elsewhere in the Gulf South, and our specialists are among the most experienced.
Click here to learn more about amyloidosis.
Make an Appointment
Diagnosing cardiac amyloidosis is complicated. Symptoms can be vague and similar to those of other common diseases. Since amyloids can lead to life-threatening organ failure, receiving an accurate diagnosis promptly is critical. To make an appointment, call 504-842-4135 or visit my.ochsner.org.
Meet the Team
Led by renowned cardiac amyloidosis expert Dr. Clement Eiswirth, Jr., Ochsner is home to an experienced, multidisciplinary team with specialties in cardiology, cardiac pathology, gastroenterology, hematology, nephrology, neurology and cardiac research–Ochsner Medical Center faculty members all with extensive experience in cardiac amyloidosis. Part of the Ochsner Heart and Vascular Center, we are committed to educating patients and physicians and spreading awareness about this disease. There is no reason to travel outside the region for leading-edge care.
Hematology
Andrew Dalavisio, MD
Carter Davis, MD
Laura Finn, MD
Cardiology
Clement Eiswirth, MD
Stacy Mandras, MD
Sapna Desai, MD
Hamang Patel, MD
Selim Krim, MD
Hector Ventura, MD
For any information regarding Cardiac Amyloidosis Program:
Contact- Rashmi Verma, MD
Cardiology Physician Research Fellow
Email v-rverma@ochsner.org
Phone-857-399-3949
Symptoms
Hidden heart failure can run in families, which is a genetic risk factor. There are other symptoms of amyloidosis, which include:
- An irregular heartbeat
- Shortness of breath
- Numbness, tingling or pain in your wrist (carpal tunnel syndrome), or feet
- Thickening of the skin or easy bruising, including purplish patches around the eye
- Frequent dizziness while change in the position (Orthostatic hypotension)
- Weakness and severe fatigue
- Ligament rupture in arm (Biceps rupture)
- An enlarged tongue
- Severe chronic back pain (Lumbar spinal stenosis)
- Poor functioning heart valve (Aortic stenosis)
- Diarrhea (possibly with blood)
- Difficulty swallowing
- Significant, unintentional weight loss
Types of Amyloidosis
There are approximately 30 different types of amyloidosis. They include:
AL amyloidosis (immunoglobulin light chain amyloidosis)
AL amyloidosis can affect your heart, kidneys, skin, nerves and liver. It was previously known as primary amyloidosis.
AA amyloidosis
This form of amyloidosis mostly affects your kidneys but can also affect your digestive tract, liver or heart. It was previously known as secondary amyloidosis. People with chronic infectious or inflammatory diseases, such as rheumatoid arthritis or inflammatory bowel disease, are at risk.
Hereditary amyloidosis
Also known as familial amyloidosis, this type affects the liver, nerves, heart and kidneys.
Wild-type ATTR (ATTRwt)
Wild-Type was once called Senile Systemic Amyloidosis and Senile Cardiac Amyloidosis, even though it’s not directly related to dementia but simply to aging.It’s prevalent old age. Deposits of TTR amyloid can be found throughout the body, but most commonly in the heart. Carpal tunnel syndrome is an early symptom.
Dialysis-related amyloidosis
People on long-term dialysis are at risk for amyloidosis. Proteins in the blood are deposited in joints and tendons, resulting in pain, stiffness and fluid in the joints, as well as carpal tunnel syndrome.
Risk Factors
While it’s true that anyone can develop amyloidosis, risk factors include:
Age
Although early onset does occur, most people with the most common type of amyloidosis (AL amyloidosis) are between 60 and 70 years old
Sex
Nearly 70 percent of people with AL amyloidosis are men.
Certain Health Factors
If you have a chronic infectious or inflammatory disease, this increases your risk of AA amyloidosis.
Genetics
Some forms of amyloidosis are hereditary.
Race
Research shows that people of African descent are at higher risk of carrying a genetic mutation associated with cardiac amyloidosis.
Kidney Dialysis
If you're on dialysis, abnormal proteins can build up in your blood and eventually be deposited in tissue. The good news is this condition is less common with modern dialysis techniques.
Diagnosing Amyloid Heart Disease
Along with consultations with Ochsner amyloidosis specialists, tests for cardiac amyloidosis may include:
- An echocardiogram
- Blood tests
- An MRI
- A cardiac biopsy
- Genetic testing
- Echocardiogram with Strain Imaging
- Technetium Pyrophosphate Scan (PYP Scan)
Ochsner is the only medical center in the region where you can get a PYP scan, an alternative to biopsy for diagnosing cardiac transthyretin (ATTR) amyloidosis in some patients.
Treatments We Offer
Your individualized treatment plan will depend on the type of amyloidosis you have as well as the source of the amyloid production.
AL amyloidosis
- high-dose chemotherapy with stem cell transplant
AA amyloidosis
- anti-inflammatory medication (steroids)
ATTR amyloidosis
- a medication called tafamidis
- heart transplant
Hereditary amyloidosis
- liver transplant
Dialysis-related amyloidosis
- changing your mode of dialysis
- kidney transplant
Supportive care may include:
- pain medication
- diuretics
- low-salt diet
- blood-thinning medication
- thickeners to add to fluid if you have trouble swallowing
- medication to control your heart rate
- compression stockings
A new drug, Vyndaqel (tafamidis meglumine), is a breakthrough drug therapy for cardiac amyloidosis, which makes it the first drug in the U.S. to be approved to treat amyloidosis. It's the first to treat cardiomyopathy of wild-type or hereditary transthyretin-mediated amyloidosis (ATTR-CM). In addition to Vyndaqel, the FDA has approved another formulation of tafamidis, Vyndamax (tafamidis). The two drugs are approved for ATTR-CM in adults to reduce cardiovascular mortality and cardiovascular-related hospitalization. This treatment is available at Ochsner.
ONPATTRO & TEGSEDI
- the treatment of polyneuropathy associated with amyloidosis
Research and Clinical Trials
In 2018, research was done at medical centers, including Ochsner, and it showed that a drug called tafamidis had good results in people with ATTR amyloidosis. Patients on tafamidis lived longer, stayed healthier longer and went to the hospital less frequently as a result of heart problems. Moreover, onpattro and tegsedi are the drugs for the treatment of polyneuropathy associated with this cardiac condition.
The Ochsner team is currently conducting research in a variety of aspects of amyloidosis. Ask your doctor for more information.
Click here for our current clinical trials.
Referring Physicians
Cardiac amyloidosis tends to be underdiagnosed or misdiagnosed. If your patient isn’t responding to treatment and has carpal tunnel syndrome, shortness of breath, and/or has had an echocardiogram that shows a ventricular wall thickness, refer them to an amyloidosis specialist at Ochsner. Our team will keep you informed every step of the way. For more information, call 504-842-4135.
